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Genome-wide association study of schizophrenia in a Japanese population.
- Source :
-
Biological psychiatry [Biol Psychiatry] 2011 Mar 01; Vol. 69 (5), pp. 472-8. Date of Electronic Publication: 2010 Sep 15. - Publication Year :
- 2011
-
Abstract
- Background: Genome-wide association studies have detected a small number of weak but strongly supported schizophrenia risk alleles. Moreover, a substantial polygenic component to the disorder consisting of a large number of such alleles has been reported by the International Schizophrenia Consortium.<br />Method: We report a Japanese genome-wide association study of schizophrenia comprising 575 cases and 564 controls. We attempted to replicate 97 markers, representing a nonredundant panel of markers derived mainly from the top 150 findings, in up to three data sets totaling 1990 cases and 5389 controls. We then attempted to replicate the observation of a polygenic component to the disorder in the Japanese and to determine whether this overlaps that seen in UK populations.<br />Results: Single-locus analysis did not reveal genome-wide support for any locus in the genome-wide association study sample (best p = 6.2 × 10(-6)) or in the complete data set in which the best supported locus was SULT6B1 (rs11895771: p = 3.7 × 10(-5) in the meta-analysis). Of loci previously supported by genome-wide association studies, we obtained in the Japanese support for NOTCH4 (rs2071287: p(meta) = 5.1 × 10(-5)). Using the approach reported by the International Schizophrenia Consortium, we replicated the observation of a polygenic component to schizophrenia within the Japanese population (p = .005). Our trans Japan-UK analysis of schizophrenia also revealed a significant correlation (best p = 7.0 × 10(-5)) in the polygenic component across populations.<br />Conclusions: These results indicate a shared polygenic risk of schizophrenia between Japanese and Caucasian samples, although we did not detect unequivocal evidence for a novel susceptibility gene for schizophrenia.<br /> (Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Alleles
Asian People
Female
Follow-Up Studies
Gene Frequency
Genetic Markers
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Japan epidemiology
Male
Middle Aged
Multifactorial Inheritance
Polymorphism, Single Nucleotide
Quality Control
Reverse Transcriptase Polymerase Chain Reaction
United Kingdom epidemiology
Genome-Wide Association Study
Schizophrenia epidemiology
Schizophrenia genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2402
- Volume :
- 69
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 20832056
- Full Text :
- https://doi.org/10.1016/j.biopsych.2010.07.010