[Mechanisms of influenza virus replication].

The influenza A virus genome consists of eight, single-stranded, negative-sense RNA segments. Unlike most negative-sense RNA viruses, transcription and replication of the influenza A virus genome occurs in the nucleus of cells. Once synthesized, the genomic RNA is exported to the cytoplasm and then to the apical plasma membrane, where a complete set of the eight viral RNA segments is packaged into progeny virions. Here, we discuss the influenza A virion structure and its replication steps in host cells.