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The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site.
- Source :
-
Nature structural & molecular biology [Nat Struct Mol Biol] 2010 Oct; Vol. 17 (10), pp. 1266-8. Date of Electronic Publication: 2010 Sep 19. - Publication Year :
- 2010
-
Abstract
- Influenza A virus neuraminidase can be classified into groups 1 and 2 on the basis of its primary structure. The main structural feature of group 1 neuraminidase is an extra cavity in the active site, the 150-cavity. Here we present the crystal structure of neuraminidase from the 2009 pandemic H1N1 influenza strain. In contrast to other characterized N1 neuraminidases, which are all members of group 1, 2009 H1N1 neuraminidase does not have a 150-cavity.
- Subjects :
- Catalytic Domain
Crystallography, X-Ray
Influenza A Virus, H1N1 Subtype genetics
Models, Molecular
Molecular Sequence Data
N-Acetylneuraminic Acid metabolism
Neuraminidase classification
Neuraminidase genetics
Protein Conformation
Sequence Alignment
Sequence Homology, Amino Acid
Influenza A Virus, H1N1 Subtype enzymology
Neuraminidase chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1545-9985
- Volume :
- 17
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Nature structural & molecular biology
- Publication Type :
- Academic Journal
- Accession number :
- 20852645
- Full Text :
- https://doi.org/10.1038/nsmb.1909