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Incidence of HIV type 1 infection, antiretroviral drug resistance, and molecular characterization in newly diagnosed individuals in Argentina: A Global Fund Project.
- Source :
-
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2011 Jan; Vol. 27 (1), pp. 17-23. Date of Electronic Publication: 2010 Sep 23. - Publication Year :
- 2011
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Abstract
- An HIV incidence estimation was performed among men who have sex with men (MSM), drug users (DUs), sex workers (SWs), and pregnant women (PW) from Argentina. Volunteers older than 18 years old without a previous HIV-positive diagnosis were included. HIV-positive samples were analyzed by the Serological Testing Algorithm for Recent HIV Seroconversion (STARHS) to estimate incidence. By partial RT-PCR and sequencing of the HIV pol gene, an HIV subtype and resistance profile were determined. A total of 12,192 volunteers were recruited from October 2006 to September 2008. A higher HIV prevalence was detected among trans SWs (33.9%, 38/112), male SWs (10.8%, 12/111), and MSM 10.4% (161/1549). HIV incidence estimates by STARHS was also higher on trans SWs (11.31 per 100 person-years), male SWs (6.06 per 100 person-years), and MSM (6.36 per 100 person-years). Antiretroviral primary resistant mutations were detected in 8.4% of the study group, with a higher frequency in female DUs (33.3%). Phylogenetic analysis showed that 124 (57.9%) samples were subtype B, 84 (39.3%) intersubtype BF recombinants, 5 (2.3%) subtype C, and 1 (0.5%) subtype F in the pol region. Subtype B was most commonly found in MSM and male SWs whereas the intersubtype BF recombinant was more prevalent in female DUs, female SWs, and PW. Given the high HIV prevalence and incidence found in most of these groups, monitoring the continuing spread of the HIV epidemic is essential for determining public health priorities, assessing the impact of interventions, and estimating current and future health care needs.
- Subjects :
- Adult
Argentina epidemiology
Cluster Analysis
Female
Genotype
HIV Infections diagnosis
HIV Infections virology
HIV-1 genetics
HIV-1 isolation & purification
Homosexuality, Male
Humans
Incidence
Male
Phylogeny
Pregnancy
Pregnancy Complications, Infectious diagnosis
Pregnancy Complications, Infectious epidemiology
Pregnancy Complications, Infectious virology
RNA, Viral genetics
Reverse Transcriptase Polymerase Chain Reaction
Sequence Analysis, DNA
Sex Work
Substance-Related Disorders complications
pol Gene Products, Human Immunodeficiency Virus genetics
Anti-Retroviral Agents pharmacology
Drug Resistance, Viral
HIV Infections epidemiology
HIV-1 classification
HIV-1 drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1931-8405
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- AIDS research and human retroviruses
- Publication Type :
- Academic Journal
- Accession number :
- 20860532
- Full Text :
- https://doi.org/10.1089/aid.2010.0013