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Therapeutic hypothermia for brain ischemia: where have we come and where do we go?
- Source :
-
Stroke [Stroke] 2010 Oct; Vol. 41 (10 Suppl), pp. S72-4. - Publication Year :
- 2010
-
Abstract
- Mild hypothermia is an established neuroprotectant in the laboratory, showing remarkable and consistent effects across multiple laboratories and models of brain injury. At the clinical level, mild hypothermia has shown benefits in patients who have experienced cardiac arrest and in some pediatric populations experiencing hypoxic brain insults. Its role, however, in stroke therapy has yet to be established. Translating preclinical data to the clinical arena presents unique challenges with regard to cooling in patients who are generally awake and may require additional therapies, such as reperfusion. We review the state of therapeutic hypothermia in ischemic and hemorrhagic stroke and provide an outlook for its role in stroke therapy.
- Subjects :
- Humans
Brain Ischemia therapy
Hypothermia, Induced trends
Stroke therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4628
- Volume :
- 41
- Issue :
- 10 Suppl
- Database :
- MEDLINE
- Journal :
- Stroke
- Publication Type :
- Academic Journal
- Accession number :
- 20876510
- Full Text :
- https://doi.org/10.1161/STROKEAHA.110.595371