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Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study.
- Source :
-
The International journal of biological markers [Int J Biol Markers] 2010 Jul-Sep; Vol. 25 (3), pp. 157-63. - Publication Year :
- 2010
-
Abstract
- Background: Data suggest that estrogen-metabolizing genes may be involved in breast cancer carcinogenesis.<br />Objective: The aim of this study was to determine the association of CYP1A1 and COMT polymorphisms with this disease.<br />Material and Methods: A pilot case-control study was conducted with Mexican women. Ninety-one breast cancer patients and 94 healthy controls were selected. Epidemiological and clinical questionnaires were answered by all participants, and genotyping data were obtained. CYP1A1 3801 T>C (rs4646903), CYP1A1 4889 A>G (rs1048943) and COMT 1947 G>A (rs4680) polymorphisms were analyzed by PCR-RFLP.<br />Results: The results showed a high risk of breast cancer in women carrying the CYP1A1 (3801 T>C) m2/m2 genotype (OR=2.52; 95%CI=1.04-6.08). The risk was higher in postmenopausal women (OR=3.38; 95%CI=1.05-10.87). No association between COMT 1947 G>A (rs4680) or CYP1A1 4889 A>G (rs1048943) and breast cancer was found.<br />Conclusions: This study suggests that the CYP1A1 (3801 T>C) m2/m2 genotype may contribute to breast cancer susceptibility in Mexican women.
- Subjects :
- Adult
Aged
Breast Neoplasms enzymology
Breast Neoplasms epidemiology
Carcinoma, Ductal, Breast enzymology
Carcinoma, Ductal, Breast epidemiology
Catechol O-Methyltransferase physiology
Contraceptive Agents, Female adverse effects
Cytochrome P-450 CYP1A1 physiology
Estrogens metabolism
Estrogens therapeutic use
Female
Genetic Predisposition to Disease
Genotype
Humans
Mexico epidemiology
Middle Aged
Neoplasm Proteins physiology
Neoplasms, Hormone-Dependent enzymology
Neoplasms, Hormone-Dependent epidemiology
Neoplasms, Hormone-Dependent genetics
Pilot Projects
Postmenopause
Reproductive History
Risk
Smoking epidemiology
Breast Neoplasms genetics
Carcinoma, Ductal, Breast genetics
Catechol O-Methyltransferase genetics
Cytochrome P-450 CYP1A1 genetics
Neoplasm Proteins genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1724-6008
- Volume :
- 25
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The International journal of biological markers
- Publication Type :
- Academic Journal
- Accession number :
- 20878621
- Full Text :
- https://doi.org/10.1177/172460081002500306