New antitumor principles, casearins A-F, for Casearia sylvestris Sw. (Flacourtiaceae).

Authors :: Itokawa H
Totsuka N
Morita H
Takeya K
Iitaka Y
Schenkel EP
Motidome M
Source :: Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 1990 Dec; Vol. 38 (12), pp. 3384-8.
Publication Year :: 1990
Abstract: New antitumor clerodane diterpenes, named casearins A-F, have been isolated from the leaves of Casearia sylvestris Sw. (Flacourtiaceae). These structures have been completely elucidated by two dimensional nuclear magnetic resonance, circular dichroism spectroscopy, X-ray analysis, and chemical evidences.

Subjects :: Animals
Cricetinae
Diterpenes pharmacology
Male
Mice
Mice, Inbred ICR
Sarcoma 180 drug therapy
Tumor Cells, Cultured drug effects
Antineoplastic Agents, Phytogenic isolation & purification
Diterpenes isolation & purification
Plants, Medicinal analysis

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