Reduced proportion of decidual DC-SIGN+ cells in human spontaneous abortion.

Authors :: Tirado-González I
Muñoz-Fernández R
Blanco O
Leno-Durán E
Abadía-Molina AC
Olivares EG
Source :: Placenta [Placenta] 2010 Nov; Vol. 31 (11), pp. 1019-22.
Publication Year :: 2010
Abstract: Recent studies showed that some functions of decidual dendritic cells appear to be essential for pregnancy. In humans, decidual dendritic cells are identifiable by their expression of DC-SIGN. We compared the subpopulations of human decidual DC-SIGN+ cells from first-trimester normal pregnancies and spontaneous abortions by flow cytometry. In normal decidua, DC-SIGN+ cells expressed antigens associated with immature myeloid dendritic cells. In samples from spontaneous abortions, we detected decidual DC-SIGN+ cells with an antigen phenotype equivalent to that of DC-SIGN+ cells from normal pregnancies, but at a significantly lower proportion (P < 0.01). Our results support the hypothesis that dendritic cells play a role in normal or pathological human pregnancy outcomes.<br /> (Copyright © 2010 Elsevier Ltd. All rights reserved.)