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Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Nov 15; Vol. 20 (22), pp. 6479-82. Date of Electronic Publication: 2010 Sep 17. - Publication Year :
- 2010
-
Abstract
- A series of N-substituted-3-[(2'-hydroxy-4'-prenyloxy)-phenyl]-5-phenyl-4,5-dihydro-(1H)-pyrazolines were synthesized and tested on human monoamine oxidase-A and -B isoforms. Structure-activity relationships and molecular modelling showed that some substitutions, such as benzyloxy or chlorine atom, improve the best interaction with active site of hMAO-B.<br /> (Copyright © 2010 Elsevier Ltd. All rights reserved.)
- Subjects :
- Humans
Inhibitory Concentration 50
Models, Molecular
Molecular Structure
Monoamine Oxidase Inhibitors chemistry
Pyrazoles chemistry
Structure-Activity Relationship
Monoamine Oxidase drug effects
Monoamine Oxidase Inhibitors chemical synthesis
Monoamine Oxidase Inhibitors pharmacology
Prenylation
Pyrazoles chemical synthesis
Pyrazoles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 20
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 20934874
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.09.061