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[Recent advances in the study of accelerated blood clearance phenomenon of PEGylated liposomes].
- Source :
-
Yao xue xue bao = Acta pharmaceutica Sinica [Yao Xue Xue Bao] 2010 Jun; Vol. 45 (6), pp. 677-83. - Publication Year :
- 2010
-
Abstract
- It is generally believed that liposomes modified with polyethylene glycol (PEG) have no or lower immunogenicity. However, based on many recent literatures, when the PEGylated liposomes were repeatedly applied to the same animal, the immune responses occurred. The first injection of PEGylated liposomes resulted in a reduction in the circulation time and an increase in hepatic and splenic accumulation of the second dose of PEGylated liposomes in a time-interval, which was called "accelerated blood clearance (ABC)" phenomenon. Such immunogenicity of PEGylated liposomes presents a barrier in the research of liposomal formulations and their use in the clinics. This review focused on the definition, the method of verification, the development of the reason for ABC phenomenon, influencing factors of ABC phenomenon, and discussed if other PEGylated nanocarriers also induce ABC phenomenon.
- Subjects :
- Animals
Antibiotics, Antineoplastic administration & dosage
Antibiotics, Antineoplastic pharmacokinetics
Doxorubicin administration & dosage
Doxorubicin pharmacokinetics
Drug Carriers
Immunoglobulin M blood
Liposomes administration & dosage
Liposomes blood
Liver metabolism
Metabolic Clearance Rate
Particle Size
Polyethylene Glycols administration & dosage
Polyethylene Glycols metabolism
Serum Albumin, Bovine pharmacokinetics
Spleen metabolism
Immunoglobulin M biosynthesis
Liposomes pharmacokinetics
Polyethylene Glycols pharmacokinetics
Spleen immunology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0513-4870
- Volume :
- 45
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Yao xue xue bao = Acta pharmaceutica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 20939173