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Primary resistance to maraviroc in a large set of R5-V3 viral sequences from HIV-1-infected patients.
- Source :
-
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2010 Dec; Vol. 65 (12), pp. 2502-4. Date of Electronic Publication: 2010 Oct 12. - Publication Year :
- 2010
-
Abstract
- Objectives: Evaluation of the prevalence of V3 mutational patterns associated with maraviroc resistance in R5-using variants.<br />Methods: V3 sequences were obtained from 809 plasma specimens collected from maraviroc-naive HIV-1-infected individuals on regular follow-up at Hospital Carlos III. Sequences considered to harbour R5-tropic viruses were examined for the presence of primary maraviroc resistance mutational patterns, as found in both in vitro and in vivo studies.<br />Results: A total of 498 R5-V3 sequences were identified. They belonged to recent HIV-1 seroconverters (55.6%), chronically antiretroviral-naive subjects (20.1%) and antiretroviral-experienced patients (24.3%). Most individuals (93.8%) were infected with HIV-1 subtype B. The overall prevalence of maraviroc resistance mutational patterns was low (≤5%). Likewise, specific polymorphisms 4L, 11R or 19S, recently found to be associated with lower clinical response to maraviroc, were found in <2% of tested samples. The rate of maraviroc resistance patterns did not differ significantly according to length of HIV-1 infection, antiretroviral exposure or HIV-1 subtype.<br />Conclusions: The prevalence of maraviroc resistance mutations is low in maraviroc-naive HIV-1-infected individuals.
- Subjects :
- Anti-HIV Agents therapeutic use
Cyclohexanes therapeutic use
HIV Envelope Protein gp120 chemistry
HIV Envelope Protein gp120 metabolism
HIV Infections virology
HIV Seropositivity drug therapy
HIV Seropositivity virology
HIV-1 genetics
HIV-1 physiology
Humans
Maraviroc
Mutation
Peptide Fragments chemistry
Peptide Fragments metabolism
Receptors, CCR5 genetics
Sequence Analysis, DNA
Triazoles therapeutic use
Viral Tropism
Anti-HIV Agents pharmacology
Cyclohexanes pharmacology
Drug Resistance, Viral genetics
HIV Envelope Protein gp120 genetics
HIV Infections drug therapy
HIV-1 drug effects
Peptide Fragments genetics
Receptors, CCR5 metabolism
Triazoles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2091
- Volume :
- 65
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Journal of antimicrobial chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 20940179
- Full Text :
- https://doi.org/10.1093/jac/dkq381