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Chemokine control of HIV-1 infection: beyond a binding competition.
- Source :
-
Retrovirology [Retrovirology] 2010 Oct 13; Vol. 7, pp. 86. Date of Electronic Publication: 2010 Oct 13. - Publication Year :
- 2010
-
Abstract
- A recent paper by Cameron et al. demonstrated that certain chemokines such as CCL19 activate cofilin and actin dynamics, promoting HIV nuclear localization and integration into resting CD4 T cells. Apparently, these chemokines synergize with the viral envelope protein, triggering cofilin and actin dynamics necessary for the establishment of viral latency. This study opens a new avenue for understanding chemokine interaction with HIV. Traditionally, chemokine control of HIV infection focuses on competitive binding and down-modulation of the co-receptors, particularly CCR5. This new study suggests that a diverse group of chemokines may also affect HIV infection through synergistic or antagonistic interaction with the viral coreceptor signaling pathways.
Details
- Language :
- English
- ISSN :
- 1742-4690
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Retrovirology
- Publication Type :
- Academic Journal
- Accession number :
- 20942936
- Full Text :
- https://doi.org/10.1186/1742-4690-7-86