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Adaptation of a novel operant orofacial testing system to characterize both mechanical and thermal pain.
- Source :
-
Behavioural brain research [Behav Brain Res] 2011 Mar 01; Vol. 217 (2), pp. 477-80. Date of Electronic Publication: 2010 Oct 23. - Publication Year :
- 2011
-
Abstract
- Mechanical pain sensitivity is characteristic of many orofacial pain conditions; however, few models exist to quantify this pain. Here we evaluated a novel adaptation of our existing operant system to characterize orofacial pain following mechanical and thermal stimuli. We demonstrate that the operant system is able to detect painful and analgesic responses to mechanical stimuli. These findings allow comparison of both mechanical and thermal stimuli using the same outcome measures.<br /> (Copyright © 2010 Elsevier B.V. All rights reserved.)
- Subjects :
- Analysis of Variance
Animals
Capsaicin adverse effects
Conditioning, Operant physiology
Disease Models, Animal
Hyperalgesia chemically induced
Male
Pain Measurement methods
Pain Threshold physiology
Rats
Rats, Sprague-Dawley
Adaptation, Physiological physiology
Facial Pain physiopathology
Hyperalgesia physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7549
- Volume :
- 217
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 20974188
- Full Text :
- https://doi.org/10.1016/j.bbr.2010.10.022