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Hemangioblastomas might derive from neoplastic transformation of neural stem cells/progenitors in the specific niche.
- Source :
-
Carcinogenesis [Carcinogenesis] 2011 Jan; Vol. 32 (1), pp. 102-9. Date of Electronic Publication: 2010 Oct 25. - Publication Year :
- 2011
-
Abstract
- The cytological origin of central nervous system hemangioblastoma (HB) remains unclear and controversial, largely owing to a lack of in-depth characterization of tumorigenic cells and their progeny tracking. We have now detected a cell subpopulation by stage-specific embryonic antigen-1 expression, which were defined as tumor-initiating cells (TICs) in both sporadic and familial HBs. These TICs subpopulations had universal neural stem cell characteristics. Nevertheless, the freshly sorted TICs endowed with potential of multi-progeny derivatives, including HB components and non-HB ingredients, depended on environmental induction in vitro. Importantly, the freshly harvested TICs formed malignant tumors by injection into conventional mice model, while did redevelop the characteristic HB-like structures within a special mice model with HB-microenvironment, indicating HB niche dependency for the TICs derivative specification. Taken together, the data of the present study suggested that HBs might derive from neoplastic transformation of neural stem cells/progenitors in the specific niche.
- Subjects :
- Adolescent
Adult
Aged
Animals
Blotting, Western
Cell Differentiation
Cell Lineage
Cell Separation
Cell Transformation, Neoplastic metabolism
Cerebellar Neoplasms metabolism
Female
Flow Cytometry
Hemangioblastoma metabolism
Humans
Immunohistochemistry
Lewis X Antigen biosynthesis
Male
Mice
Middle Aged
Neoplastic Stem Cells metabolism
Neural Stem Cells metabolism
Stem Cell Niche cytology
Young Adult
Cell Transformation, Neoplastic pathology
Cerebellar Neoplasms pathology
Hemangioblastoma pathology
Neoplastic Stem Cells cytology
Neural Stem Cells pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2180
- Volume :
- 32
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Carcinogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 20974685
- Full Text :
- https://doi.org/10.1093/carcin/bgq214