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Relationship between degree of chromosomal aberration and survival in intestinal-type gastric cancer - a preliminary report based on three cases of hepatic metastasized gastric cancer with long-time survival.
- Source :
-
Onkologie [Onkologie] 2010; Vol. 33 (11), pp. 591-6. Date of Electronic Publication: 2010 Oct 25. - Publication Year :
- 2010
-
Abstract
- Background: Gastric cancer is one of the most frequent malignancies worldwide. More than 50% of all patients present with advanced stage of disease, with long-time survival of less than 5%. In selected subgroups, palliative gastric resection seems to be beneficial for survival and improved quality of the remaining life time, but is still controversially discussed.<br />Patients and Methods: We report 3 cases of patients with intestinal-type advanced gastric cancer. All patients presented preoperatively with stage IV disease with liver metastases. The patients underwent palliative gastric resection and subsequent palliative chemotherapy. We performed a genome-wide DNA analysis of 9 gastric cancer tissue specimens using the DNA microchip array technique.<br />Results: 4 and 6 years after palliative surgery and chemotherapy, 2 of the patients show no signs of recurrence, while the third patient shows stable disease under third-line chemotherapy 4 years after the initial diagnosis. Comparative genetic analysis of 9 gastric cancer tissue specimens suggested that the degree of chromosomal aberration was closely related to survival for intestinal-type gastric cancers.<br />Conclusions: Palliative gastric resection is beneficial for survival and quality of life in selected patients. Determination of the degree of chromosomal aberrations might be helpful in predicting the response on multimodal treatment in intestinal-type gastric cancer. A better understanding of molecular biology is needed to define prognosis markers and molecular targets.<br /> (Copyright © 2010 S. Karger AG, Basel.)
- Subjects :
- Adult
Female
Genetic Predisposition to Disease genetics
Germany
Humans
Incidence
Intestinal Neoplasms genetics
Intestinal Neoplasms mortality
Intestinal Neoplasms therapy
Liver Neoplasms genetics
Liver Neoplasms prevention & control
Liver Neoplasms therapy
Longitudinal Studies
Male
Pilot Projects
Risk Assessment
Risk Factors
Statistics as Topic
Stomach Neoplasms therapy
Survival Analysis
Survival Rate
Chromosome Aberrations
Genetic Predisposition to Disease epidemiology
Liver Neoplasms mortality
Liver Neoplasms secondary
Palliative Care statistics & numerical data
Stomach Neoplasms genetics
Stomach Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0240
- Volume :
- 33
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Onkologie
- Publication Type :
- Academic Journal
- Accession number :
- 20975305
- Full Text :
- https://doi.org/10.1159/000321143