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Estrogen receptors and signaling pathways in lactotropes and somatotropes.
- Source :
-
Neuroendocrinology [Neuroendocrinology] 2010; Vol. 92 (4), pp. 215-23. Date of Electronic Publication: 2010 Oct 27. - Publication Year :
- 2010
-
Abstract
- Estrogens are crucial determinants in the regulation of anterior pituitary function and maintenance of tissue homeostasis. Estrogen actions in this gland are exerted through both classical and non-classical mechanisms of action. This review summarizes the expression of classical α- and β-estrogen receptors and variant isoforms of estrogen receptors in anterior pituitary cell subpopulations. We also analyze estrogen receptor signaling pathways involved in estrogenic actions in the anterior pituitary gland, especially in lactotropes and somatotropes. Complex interactions between multiple signaling pathways are involved in estrogen regulation of hormone secretion, cell proliferation and cell death in this gland. Insight into these pituitary responses to estrogens would help to understand pituitary function and tumorigenesis.<br /> (Copyright © 2010 S. Karger AG, Basel.)
- Subjects :
- Animals
Humans
Lactotrophs metabolism
Models, Biological
Pituitary Gland, Anterior metabolism
Pituitary Gland, Anterior physiology
Receptors, Estrogen genetics
Receptors, Estrogen metabolism
Signal Transduction genetics
Signal Transduction physiology
Somatotrophs metabolism
Lactotrophs physiology
Receptors, Estrogen physiology
Somatotrophs physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0194
- Volume :
- 92
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neuroendocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 20980730
- Full Text :
- https://doi.org/10.1159/000321683