dnaX36 Mutator of Escherichia coli: effects of the {tau} subunit of the DNA polymerase III holoenzyme on chromosomal DNA replication fidelity.

Authors :: Gawel D
Jonczyk P
Fijalkowska IJ
Schaaper RM
Source :: Journal of bacteriology [J Bacteriol] 2011 Jan; Vol. 193 (1), pp. 296-300. Date of Electronic Publication: 2010 Oct 29.
Publication Year :: 2011
Abstract: The Escherichia coli dnaX36 mutant displays a mutator effect, reflecting a fidelity function of the dnaX-encoded τ subunit of the DNA polymerase III (Pol III) holoenzyme. We have shown that this fidelity function (i) applies to both leading- and lagging-strand synthesis, (ii) is independent of Pol IV, and (iii) is limited by Pol II.

Subjects :: Chromosomes, Bacterial
DNA Polymerase III genetics
Escherichia coli classification
Escherichia coli Proteins genetics
Gene Expression Regulation, Bacterial physiology
Mutation
Transcription Factors genetics
DNA Polymerase III metabolism
DNA Replication physiology
Escherichia coli genetics
Escherichia coli metabolism
Escherichia coli Proteins metabolism
Transcription Factors metabolism

Full Text Access

Tools