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Evidence of oxidative stress in relation to feeding type during early life in premature infants.
- Source :
-
Pediatric research [Pediatr Res] 2011 Feb; Vol. 69 (2), pp. 160-4. - Publication Year :
- 2011
-
Abstract
- Morbidity in the premature (PT) infant may reflect difficult adaptation to oxygen. We hypothesized that feeding including formula feeding (F) and feeding mother's milk (HM) with added fortifier would affect redox status. Therefore, 65 PT infants (birth weight: 1146 ± 261 g; GA: 29 ± 2.5 wk; mean ± SD) were followed biweekly, once oral feeds were introduced. Feeding groups: F (>75% total feeds) and HM (>75% total feeds) were further subdivided according to human milk fortifier (HMF) content of 0-19, 20-49, and ≥ 50%. Oxidative stress was quantified by F2-isoprostanes (F2-IsoPs) in urine, protein carbonyls, and oxygen radical absorbance capacity (ORAC) in plasma. F2-IsoPs (ng/mg creatinine): 0-2 wk, 125 ± 63; 3-4 wk, 191 ± 171; 5-6 wk, 172 ± 83; 7-8 wk, 211 ± 149; 9-10 wk, 222 ± 121; and >10 wk, 183 ± 67. Protein carbonyls from highest [2.41 ± 0.75 (n = 9)] and lowest [2.25 ± 0.89 (n = 12) pmol/μg protein] isoprostane groups did not differ. ORAC: baseline, 6778 ± 1093; discharge, 6639 ± 735 [full term 4 and 12 M, 9010 ± 600 mg (n = 12) TE]. Highest isoprostane values occurred in infants with >50% of their mother's milk fortified. Further research on HMF is warranted.
- Subjects :
- Analysis of Variance
Biomarkers blood
Biomarkers urine
Catalase blood
F2-Isoprostanes urine
Female
Gestational Age
Glutathione Peroxidase blood
Humans
Infant, Newborn
Infant, Very Low Birth Weight
Male
Oxidation-Reduction
Pilot Projects
Protein Carbonylation
Superoxide Dismutase blood
Bottle Feeding
Breast Feeding
Infant Formula
Infant, Premature
Oxidative Stress
Subjects
Details
- Language :
- English
- ISSN :
- 1530-0447
- Volume :
- 69
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pediatric research
- Publication Type :
- Academic Journal
- Accession number :
- 21045751
- Full Text :
- https://doi.org/10.1203/PDR.0b013e3182042a07