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Photodynamic therapy for basal cell carcinoma: clinical and pathological determinants of response.
- Source :
-
Journal of the European Academy of Dermatology and Venereology : JEADV [J Eur Acad Dermatol Venereol] 2011 Aug; Vol. 25 (8), pp. 896-901. Date of Electronic Publication: 2010 Nov 04. - Publication Year :
- 2011
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Abstract
- Background: Photodynamic therapy (PDT) is increasingly used in the treatment of basal cell carcinoma (BCC). However, scant information is available about the impact of both patient- and lesion-related characteristics on the effectiveness of therapy. Therefore, on the basis of the current data, it is difficult to draw clear-cut indications to use PDT for treatment of BCC in clinical practice.<br />Objective: To investigate the clinical and pathological determinants of response of BCC to PDT with methylaminolevulinate (MAL) and red light.<br />Methods: The clinical and pathological characteristics of 194 BCCs in 135 patients, treated with MAL-PDT, were evaluated. Lesions were treated with MAL-PDT according to established methods and the response was assessed by clinical follow-up of the patients.<br />Results: Complete response to PDT was 62%, with a better response for superficial BCC (95/116, 82%) than nodular BCC (26/78, 33%). When determinants of response were analysed, the nodular type and the location on the limbs emerged as significant clinical predictors of failure. Among the pathological characteristics, the nodular and infiltrative histotypes, as well as ulceration and tumour thickness were associated with a lower response to therapy. Patients' age and gender, as well as the size of the lesions, were not found to be significant predictors.<br />Conclusions: Optimization of PDT procedure for BCC requires a careful selection of the lesions. In particular, superficial BCCs, preferentially located on the trunk, show the best therapeutic response.<br /> (© 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology.)
- Subjects :
- Age Factors
Aged
Aged, 80 and over
Aminolevulinic Acid therapeutic use
Extremities pathology
Female
Head and Neck Neoplasms drug therapy
Head and Neck Neoplasms pathology
Humans
Male
Middle Aged
Retrospective Studies
Sex Factors
Torso pathology
Treatment Outcome
Aminolevulinic Acid analogs & derivatives
Carcinoma, Basal Cell drug therapy
Carcinoma, Basal Cell pathology
Photochemotherapy
Photosensitizing Agents therapeutic use
Skin Neoplasms drug therapy
Skin Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1468-3083
- Volume :
- 25
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of the European Academy of Dermatology and Venereology : JEADV
- Publication Type :
- Academic Journal
- Accession number :
- 21054566
- Full Text :
- https://doi.org/10.1111/j.1468-3083.2010.03877.x