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The safety of the H1N1 influenza A vaccine in egg allergic individuals.
- Source :
-
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology [Ann Allergy Asthma Immunol] 2010 Nov; Vol. 105 (5), pp. 387-93. - Publication Year :
- 2010
-
Abstract
- Background: The safety of H1N1 vaccine is unknown in egg allergic (EA) recipients.<br />Objectives: To establish the safety of administering H1N1 vaccine and to evaluate the predictability of H1N1 skin testing in EA patients.<br />Methods: In a controlled, prospective trial, H1N1 skin testing and vaccination was compared between EA patients (n = 105) and non-EA controls (n = 19). Those with negative H1N1 skin test results received a full H1N1 dose; those with a positive skin test result received a graded challenge (10%, 90%). Booster vaccine, if required, was given as a single dose from a different lot without prior testing.<br />Results: Prick and intradermal test results were positive in 3 (2.4%) of 124 and 41 (33.1%) of 124 study participants, respectively. Forty-one individuals received a 2-step graded vaccine challenge, including 13 of 25 with a history of egg anaphylaxis. No significant allergic reactions resulted from either method of vaccination or from subsequent booster doses.<br />Conclusion: All study participants received the H1N1 vaccine without significant allergic reactions. Skin testing is unnecessary and does not predict vaccine tolerance. All study participants who received a graded challenge tolerated a single dose booster from a different, untested lot, including 7 individuals with a history of egg-induced anaphylaxis. We recommend administration of H1N1 vaccine to EA children without prior skin testing or graded challenge dosing.<br /> (Copyright © 2010 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Anaphylaxis
Child
Child, Preschool
Female
Follow-Up Studies
Food Hypersensitivity complications
Food Hypersensitivity physiopathology
Humans
Immunization, Secondary
Infant
Influenza Vaccines adverse effects
Influenza, Human complications
Influenza, Human physiopathology
Influenza, Human prevention & control
Male
Predictive Value of Tests
Skin Tests
Young Adult
Food Hypersensitivity immunology
Influenza A Virus, H1N1 Subtype immunology
Influenza Vaccines administration & dosage
Influenza, Human immunology
Vaccination
Subjects
Details
- Language :
- English
- ISSN :
- 1534-4436
- Volume :
- 105
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 21055666
- Full Text :
- https://doi.org/10.1016/j.anai.2010.08.015