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Toxic effects of oral 2-amino-4,6-dinitrotoluene in the Western fence lizard (Sceloporus occidentalis).
- Source :
-
Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2011 Feb; Vol. 159 (2), pp. 466-73. Date of Electronic Publication: 2010 Nov 10. - Publication Year :
- 2011
-
Abstract
- The compound 2-amino-4,6-dinitrotoluene (2A-DNT) was evaluated under laboratory conditions in the Western fence lizard (Sceloporus occidentalis) to assess the potential for reptile toxicity. Oral LD(50) values were 1406 and 1867 mg/kg for male and female lizards, respectively. Based on responses from a 14-day subacute study, a 60-day subchronic experiment followed where lizards were orally dosed at 0, 5, 15, 20, 25, 30 mg/kg-d. At day 60, number of days and survivors, food consumption, and change in body weight were inversely related to dose. Signs of toxicity were characterized by anorexia and generalized cachexia. Significant adverse histopathology was observed in hepatic tissue at ≥ 15 mg/kg-d, consistent with hepatocellular transdifferentiation. Based on survival, loss of body weight, diminished food intake, changes in liver, kidney, and testes, and increased blood urea nitrogen, these data suggest a LOAEL of 15 mg/kg-d and a NOAEL of 5 mg/kg-d in S. occidentalis.<br /> (Published by Elsevier Ltd.)
- Subjects :
- Aniline Compounds administration & dosage
Aniline Compounds metabolism
Animals
Body Weight drug effects
Dose-Response Relationship, Drug
Environmental Pollutants administration & dosage
Environmental Pollutants metabolism
Explosive Agents administration & dosage
Explosive Agents metabolism
Female
Lizards growth & development
Male
Aniline Compounds toxicity
Environmental Pollutants toxicity
Explosive Agents toxicity
Lizards metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6424
- Volume :
- 159
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Environmental pollution (Barking, Essex : 1987)
- Publication Type :
- Academic Journal
- Accession number :
- 21067851
- Full Text :
- https://doi.org/10.1016/j.envpol.2010.10.018