Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst.

Authors :: Harmrolfs K
Brünjes M
Dräger G
Floss HG
Sasse F
Taft F
Kirschning A
Source :: Chembiochem : a European journal of chemical biology [Chembiochem] 2010 Dec 10; Vol. 11 (18), pp. 2517-20.
Publication Year :: 2010

Subjects :: Actinomycetales genetics
Actinomycetales metabolism
Amide Synthases genetics
Antineoplastic Agents pharmacology
Cell Line, Tumor
Cell Proliferation drug effects
Cyclization
Cysteamine analogs & derivatives
Humans
Maytansine chemistry
Maytansine metabolism
Maytansine pharmacology
Mutation
Actinomycetales enzymology
Amide Synthases metabolism
Maytansine analogs & derivatives

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