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Role of Helicobacter pylori in the pathogenesis of hyperemesis gravidarum.
- Source :
-
Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2011 Oct; Vol. 284 (4), pp. 843-7. Date of Electronic Publication: 2010 Nov 16. - Publication Year :
- 2011
-
Abstract
- Purpose: To evaluate the role of Helicobacter pylori (H. pylori) in the pathogenesis of hyperemesis gravidarum (HG) and the value of adding a non teratogenic regimen for its treatment in intractable cases.<br />Methods: Eighty hyperemesis gravidarum cases were recruited from Ain Shams University out patient clinics. A complete history was taken including history of medical disorders and chronic medications intake as non steroidal anti-inflammatory drugs. After general and local examination, ultrasound was done for all cases to exclude obstetric causes of hyperemesis. Eighty normal pregnant women acted as control. Serum test for H. pylori IgG antibody titre was done for all patients and controls.<br />Results: Seventy-one cases among the 80 HG cases and twenty-four out of the 80 controls were H. pylori positive. Eight HG cases developed severe intractable vomiting. Three of them developed attacks of hematemesis. Gastroscopy done for the eight cases revealed antral gastritis and duodenitis. Gastric and duodenal erosions were found in two cases. The eight patients received a non teratogenic regimen for treatment. Attacks of vomiting decreased and pregnancy continued till delivery of healthy newborns.<br />Conclusion: Screening for H. pylori should be added to the investigations of hyperemesis gravidarum cases. Non teratogenic treatment can be considered in intractable cases.
- Subjects :
- Adult
Ampicillin administration & dosage
Anti-Infective Agents administration & dosage
Anti-Ulcer Agents administration & dosage
Antibodies, Bacterial analysis
Enzyme-Linked Immunosorbent Assay
Female
Gastroscopy
Helicobacter Infections diagnostic imaging
Helicobacter Infections drug therapy
Helicobacter Infections pathology
Helicobacter pylori immunology
Humans
Hyperemesis Gravidarum diagnostic imaging
Hyperemesis Gravidarum drug therapy
Hyperemesis Gravidarum pathology
Metronidazole administration & dosage
Pregnancy
Pregnancy Complications, Infectious diagnostic imaging
Pregnancy Complications, Infectious drug therapy
Pregnancy Complications, Infectious pathology
Pregnancy Trimester, First
Prenatal Care
Prenatal Diagnosis
Prospective Studies
Ranitidine administration & dosage
Treatment Outcome
Ultrasonography
Helicobacter Infections microbiology
Helicobacter pylori isolation & purification
Hyperemesis Gravidarum microbiology
Pregnancy Complications, Infectious microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0711
- Volume :
- 284
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Archives of gynecology and obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 21079980
- Full Text :
- https://doi.org/10.1007/s00404-010-1759-8