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Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures.
- Source :
-
Journal of neuroinflammation [J Neuroinflammation] 2010 Nov 18; Vol. 7, pp. 81. Date of Electronic Publication: 2010 Nov 18. - Publication Year :
- 2010
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Abstract
- Under certain experimental conditions, neurotrophic factors may reduce epileptogenesis. We have previously reported that local, intrahippocampal supplementation of fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF) increases neurogenesis, reduces neuronal loss, and reduces the occurrence of spontaneous seizures in a model of damage-associated epilepsy. Here, we asked if these possibly anti-epileptogenic effects might involve anti-inflammatory mechanisms. Thus, we used a Herpes-based vector to supplement FGF-2 and BDNF in rat hippocampus after pilocarpine-induced status epilepticus that established an epileptogenic lesion. This model causes intense neuroinflammation, especially in the phase that precedes the occurrence of spontaneous seizures. The supplementation of FGF-2 and BDNF attenuated various parameters of inflammation, including astrocytosis, microcytosis and IL-1β expression. The effect appeared to be most prominent on IL-1β, whose expression was almost completely prevented. Further studies will be needed to elucidate the molecular mechanism(s) for these effects, and for that on IL-1β in particular. Nonetheless, the concept that neurotrophic factors affect neuroinflammation in vivo may be highly relevant for the understanding of the epileptogenic process.
- Subjects :
- Animals
Electroencephalography
Interleukin-1beta metabolism
Random Allocation
Rats
Recurrence
Seizures metabolism
Seizures physiopathology
Status Epilepticus chemically induced
Status Epilepticus pathology
Brain-Derived Neurotrophic Factor pharmacology
Fibroblast Growth Factor 2 pharmacology
Hippocampus drug effects
Hippocampus pathology
Hippocampus physiopathology
Inflammation pathology
Seizures pathology
Seizures prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1742-2094
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of neuroinflammation
- Publication Type :
- Academic Journal
- Accession number :
- 21087489
- Full Text :
- https://doi.org/10.1186/1742-2094-7-81