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Cytotoxic triterpenoids from Maytenus retusa.
- Source :
-
Journal of natural products [J Nat Prod] 2010 Dec 27; Vol. 73 (12), pp. 2029-34. Date of Electronic Publication: 2010 Nov 23. - Publication Year :
- 2010
-
Abstract
- Seven new triterpenoids (1-7) and 36 known compounds were isolated from the root bark of Maytenus retusa. Their structures were determined by 1D and 2D spectroscopic studies. Several compounds were evaluated for their cytotoxicity against the human tumor cell lines HL-60 and MCF-7. Some of them were cytotoxic, with IC(50) values ranging between 0.2 and 4.7 μM.
- Subjects :
- Antineoplastic Agents, Phytogenic chemistry
Drug Screening Assays, Antitumor
HL-60 Cells
Humans
Inhibitory Concentration 50
Molecular Conformation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Bark chemistry
Triterpenes chemistry
Antineoplastic Agents, Phytogenic isolation & purification
Antineoplastic Agents, Phytogenic pharmacology
Maytenus chemistry
Plants, Medicinal chemistry
Triterpenes isolation & purification
Triterpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 73
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 21090801
- Full Text :
- https://doi.org/10.1021/np100517u