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Neuroprotective properties of afobazole in repeated hemorrhagic stroke modeling in aged rats.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2010 Aug; Vol. 149 (2), pp. 204-7. - Publication Year :
- 2010
-
Abstract
- Intraperitoneal administration of afobazole in a dose of 0.1 mg/kg over 2 weeks after repeated modeling of intracerebral post-traumatic hematoma reduces animal mortality, decreases motor coordination disturbances, and improves learning and memory processes in rats.
- Subjects :
- Age Factors
Animals
Ataxia etiology
Benzimidazoles administration & dosage
Benzimidazoles therapeutic use
Cerebral Hemorrhage, Traumatic complications
Cerebral Hemorrhage, Traumatic mortality
Injections, Intraperitoneal
Male
Morpholines administration & dosage
Morpholines therapeutic use
Neuroprotective Agents administration & dosage
Neuroprotective Agents therapeutic use
Rats
Ataxia drug therapy
Benzimidazoles pharmacology
Cerebral Hemorrhage, Traumatic drug therapy
Learning drug effects
Memory drug effects
Morpholines pharmacology
Neuroprotective Agents pharmacology
Subjects
Details
- Language :
- English; Russian
- ISSN :
- 1573-8221
- Volume :
- 149
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 21113492
- Full Text :
- https://doi.org/10.1007/s10517-010-0908-1