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Effects of the soluble fiber complex PolyGlycopleX® (PGX®) on glycemic control, insulin secretion, and GLP-1 levels in Zucker diabetic rats.
- Source :
-
Life sciences [Life Sci] 2011 Feb 28; Vol. 88 (9-10), pp. 392-9. Date of Electronic Publication: 2010 Nov 30. - Publication Year :
- 2011
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Abstract
- Aims: The effects of the novel water soluble, viscous fiber complex PolyGlycopleX® [(α-D-glucurono-α-D-manno-β-D-manno-β-D-gluco), (α-L-gulurono-β-D mannurono), β-D-gluco-β-D-mannan (PGX®)] on body weight, food consumption, glucose, insulin, and glucagon-like peptide (GLP-1) levels were determined in Zucker diabetic rats (ZDFs). Such fibers are thought to improve glycemic control through increased GLP-1 induced insulin secretion.<br />Main Methods: ZDFs were treated 12 weeks with normal rodent chow supplemented with cellulose (control, inert fiber), inulin or PGX® at 5% wt/wt and effects on body weight, glycemic control, and GLP-1 determined.<br />Key Findings: In the fed state, PGX® reduced blood glucose compared to the other groups from week 5 until study termination while insulin was significantly elevated when measured at week 9, suggesting an insulin secretagogue effect. Fasting blood glucose was similar among groups until 7-8 weeks when levels began to climb with a modest reduction caused by PGX®. An oral glucose tolerance test in fasted animals (week 11) showed no change in insulin sensitivity scores among diets, suggesting an insulinotropic effect for PGX® rather than increased insulin sensitivity. PGX® increased plasma levels of GLP-1, while HbA(1c) was markedly reduced by PGX®. Body weights were not changed despite a significant reduction in food consumption induced by PGX® up to week 8 when the PGX®-treated group showed an increase in body weight despite a continued reduction in food consumption.<br />Significance: PGX® improved glycemic control and reduced protein glycation, most likely due to the insulin secretagogue effects of increased GLP-1.<br /> (Copyright © 2010 Elsevier Inc. All rights reserved.)
- Subjects :
- Animal Feed
Animals
Body Weight drug effects
Cellulose administration & dosage
Drug Combinations
Eating drug effects
Glucose Tolerance Test
Glycated Hemoglobin metabolism
Hyperglycemia blood
Male
Rats
Rats, Zucker
Alginates administration & dosage
Blood Glucose metabolism
Diabetes Mellitus, Type 2 blood
Glucagon-Like Peptide 1 blood
Hyperglycemia diet therapy
Insulin blood
Polysaccharides, Bacterial administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0631
- Volume :
- 88
- Issue :
- 9-10
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 21115020
- Full Text :
- https://doi.org/10.1016/j.lfs.2010.11.014