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Prenatal exposure to non-ionizing radiation: effects of WiFi signals on pregnancy outcome, peripheral B-cell compartment and antibody production.
- Source :
-
Radiation research [Radiat Res] 2010 Dec; Vol. 174 (6), pp. 732-40. Date of Electronic Publication: 2010 Sep 28. - Publication Year :
- 2010
-
Abstract
- During embryogenesis, the development of tissues, organs and systems, including the immune system, is particularly susceptible to the effects of noxious agents. We examined the effects of prenatal (in utero) exposure to WiFi signals on pregnancy outcome and the immune B-cell compartment, including antibody production. Sixteen mated (plug-positive) female mice were assigned to each of the following groups: cage control, sham-exposed and microwave-exposed (WiFi signals at 2.45 GHz, whole body, SAR 4 W/kg, 2 h/day, 14 consecutive days starting 5 days after mating). No effects due to exposure to WiFi signals during pregnancy on mating success, number of newborns/mother and body weight at birth were found. Newborn mice were left to grow until 5 or 26 weeks of age, when immunological analyses were performed. No differences due to exposure were found in spleen cell number, B-cell frequency or antibody serum levels. When challenged in vitro with LPS, B cells from all groups produced comparable amounts of IgM and IgG, and proliferated at a similar level. All these findings were consistently observed in the female and male offspring at both juvenile (5 weeks) and adult (26 weeks) ages. Stress-associated effects as well as age- and/or sex-related differences were observed for several parameters. In conclusion, our results do not show any effect on pregnancy outcome or any early or late effects on B-cell differentiation and function due to prenatal exposure to WiFi signals.
- Subjects :
- Animals
B-Lymphocytes immunology
Female
Fetus immunology
Lipopolysaccharides pharmacology
Lymphocyte Activation radiation effects
Male
Mice
Mice, Inbred C57BL
Pregnancy
Pregnancy Outcome
Antibody Formation radiation effects
B-Lymphocytes radiation effects
Fetus radiation effects
Microwaves adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1938-5404
- Volume :
- 174
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Radiation research
- Publication Type :
- Academic Journal
- Accession number :
- 21128797
- Full Text :
- https://doi.org/10.1667/RR2255.1