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Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2011 Feb 28; Vol. 47 (8), pp. 2321-3. Date of Electronic Publication: 2010 Dec 13. - Publication Year :
- 2011
-
Abstract
- Precursor-fed cultivation of endophytic Chaetomium globosum 1C51 afforded nine novel "unnatural" halogenated chaetoglobosins including those with more preferable immunosuppressive activity.
- Subjects :
- Animals
Cells, Cultured
Chaetomium chemistry
Halogenation
Immunosuppressive Agents chemical synthesis
Immunosuppressive Agents toxicity
Indole Alkaloids chemical synthesis
Indole Alkaloids toxicity
Magnetic Resonance Spectroscopy
Mice
Immunosuppressive Agents chemistry
Indole Alkaloids chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 47
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 21152613
- Full Text :
- https://doi.org/10.1039/c0cc04183a