Hemostimulating effects of immobilized hyaluronidase and their mechanisms during cytostatic-induced myelosuppression.

Authors :: Dygai AM
Artamonov AV
Bekarev AA
Vereschagin EI
Zhdanov VV
Zyuz'kov GN
Udut EV
Khrichkova TY
Simanina EV
Stavrova LA
Miroshnichenko LA
Chaikovskiy AV
Madonov PG
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2010 Oct; Vol. 149 (5), pp. 594-7.
Publication Year :: 2010
Abstract: We studied the effect of immobilized hyaluronidase on hemopoiesis under conditions of cyclophosphamide-induced suppression. The preparation was shown to possess high hemostimulating activity. The stimulatory effect of hyaluronidase on the erithron was more pronounced than its effect on the granulocytic hemopoietic stem due to increase in functional activity of hemopoietic precursors and hemopoiesis-inducing microenvironment.

Subjects :: Animals
Cyclophosphamide pharmacology
Hematopoietic Stem Cells drug effects
Mice
Mice, Inbred CBA
Enzymes, Immobilized pharmacology
Hematopoiesis drug effects
Hyaluronoglucosaminidase pharmacology

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