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Palladium-catalyzed indole, pyrrole, and furan arylation by aryl chlorides.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2011 Jan 21; Vol. 76 (2), pp. 471-83. Date of Electronic Publication: 2010 Dec 30. - Publication Year :
- 2011
-
Abstract
- The palladium-catalyzed direct arylation of indoles, pyrroles, and furans by aryl chlorides has been demonstrated. The method employs a palladium acetate catalyst, 2-(dicyclohexylphosphino)-biphenyl ligand, and an inorganic base. Electron-rich and electron-poor aryl chlorides as well as chloropyridine coupling partners can be used, and arylated heterocycles are obtained in moderate to good yields. Optimization of base, ligand, and solvent is required for achieving best results.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 76
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 21192652
- Full Text :
- https://doi.org/10.1021/jo1018969