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Increased left ventricular torsion in hypertrophic cardiomyopathy mutation carriers with normal wall thickness.
- Source :
-
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance [J Cardiovasc Magn Reson] 2011 Jan 10; Vol. 13, pp. 3. Date of Electronic Publication: 2011 Jan 10. - Publication Year :
- 2011
-
Abstract
- Background: Increased left ventricular (LV) torsion has been observed in patients with manifest familial hypertrophic cardiomyopathy (HCM), and is thought to be caused by subendocardial dysfunction. We hypothesize that increased LV torsion is already present in healthy mutation carriers with normal wall thickness.<br />Methods: Seventeen carriers with an LV wall thickness <10 mm, and seventeen age and gender matched controls had cardiovascular magnetic resonance (CMR) cine imaging and tissue tagging. LV volumes and mass were calculated from the cine images. LV torsion, torsion rate, endocardial circumferential strain and torsion-to-endocardial-circumferential-shortening (TECS) ratio, which reflects the transmural distribution in contractile function, were determined using tissue tagging.<br />Results: LV volumes, mass and circumferential strain were comparable between groups, whereas LV ejection fraction, torsion and TECS-ratio were increased in carriers compared to controls (63 ± 3% vs. 60 ± 3%, p = 0.04, 10.1 ± 2.5° vs. 7.7 ± 1.2°, p = 0.001, and 0.52 ± 0.14°/% vs. 0.42 ± 0.10°/%, p = 0.02, respectively).<br />Conclusions: Carriers with normal wall thickness display increased LV torsion and TECS-ratio with respect to controls, which might be due to subendocardial myocardial dysfunction. As similar abnormalities are observed in patients with manifest HCM, the changes in healthy carriers may be target for clinical intervention to delay or prevent the onset of hypertrophy.
- Subjects :
- Adult
Cardiomyopathy, Hypertrophic, Familial genetics
Cardiomyopathy, Hypertrophic, Familial pathology
Case-Control Studies
Female
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging, Cine
Male
Middle Aged
Netherlands
Torsion Abnormality genetics
Torsion Abnormality pathology
Ventricular Dysfunction, Left genetics
Ventricular Dysfunction, Left pathology
Cardiomyopathy, Hypertrophic, Familial physiopathology
Mutation
Myocardial Contraction genetics
Torsion Abnormality physiopathology
Ventricular Dysfunction, Left physiopathology
Ventricular Function, Left genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1532-429X
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
- Publication Type :
- Academic Journal
- Accession number :
- 21219655
- Full Text :
- https://doi.org/10.1186/1532-429X-13-3