Action of six commonly used benzodiazepines on isolated guinea-pig ileum preparation.

Authors :: Huck S
Stacher G
Gogolák G
Stumpf C
Source :: Archives internationales de pharmacodynamie et de therapie [Arch Int Pharmacodyn Ther] 1975 Nov; Vol. 218 (1), pp. 77-83.
Publication Year :: 1975
Abstract: The spasmolytic activity of six commonly used benzodiazepines was investigated on isolated guinea-pig ileum preparation. All six substances proved to be non-competitive antagonists of carbachol and barium chloride, the pD'2 values ranging between 3.23 and 4.37 in the presence of either agonist. The significance of these findings is discussed.

Subjects :: Animals
Barium antagonists & inhibitors
Benzodiazepines
Carbachol antagonists & inhibitors
Guinea Pigs
In Vitro Techniques
Muscle Contraction drug effects
Papaverine pharmacology
Anti-Anxiety Agents pharmacology
Ileum drug effects

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