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Immunohistochemical expression of fibronectin and C5b-9 in the myocardium in cases of fatal ethanol intoxication.
- Source :
-
International journal of legal medicine [Int J Legal Med] 2011 Jul; Vol. 125 (4), pp. 537-42. Date of Electronic Publication: 2011 Jan 14. - Publication Year :
- 2011
-
Abstract
- Data from the literature indicate that the pulmonary pressure rises in cases of ethanol intake. We have recently proposed a method for the detection of prevalent right ventricular damage in cases of fatal pulmonary thromboembolism and pulmonary fat embolism. In the present study, we compared the expression of the antibodies against fibronectin and C5b-9 in 19 cases of lethal alcohol intoxications (study group: 5 females, 14 males, mean age 46 years, mean blood ethanol concentration 3.5‰, min. 2.11‰, max. 5.31‰) to a group of 26 cases of fatal pulmonary thromboembolism (PE; group 2: 16 females, 10 males, mean age 56 years). Moreover, a group of 15 cases of hanging (group 3: 5 females, 10 males, mean age 50 years) as well as a group of 18 cases of myocardial infarction (group 4: 5 females, 13 males, mean age 61 years) were investigated as examples of typical cardiac damage due to global hypoxia during agony and ischemic damage, respectively. The results of this study show that fresh cardiac damage can be detected at both ventricles in cases of fatal ethanol intoxication with the antibody against fibronectin. The damage is prevalently localised at the right ventricle (RV), as already observed in cases of acute pulmonary hypertension determining right heart failure. The degree of damage at the RV in cases of ethanol intoxications is lower than the one observed in cases of fatal PE.
- Subjects :
- Adult
Aged
Aged, 80 and over
Asphyxia pathology
Cause of Death
Ethanol blood
Female
Heart Ventricles pathology
Humans
Hypertension, Pulmonary pathology
Hypoxia pathology
Male
Middle Aged
Myocardial Infarction pathology
Myocardial Ischemia pathology
Pulmonary Embolism pathology
Alcoholic Intoxication pathology
Complement Membrane Attack Complex analysis
Ethanol poisoning
Fibronectins analysis
Myocardium pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1437-1596
- Volume :
- 125
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of legal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 21234582
- Full Text :
- https://doi.org/10.1007/s00414-011-0547-8