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Perceived morbidity and community burden after a Chikungunya outbreak: the TELECHIK survey, a population-based cohort study.
- Source :
-
BMC medicine [BMC Med] 2011 Jan 14; Vol. 9, pp. 5. Date of Electronic Publication: 2011 Jan 14. - Publication Year :
- 2011
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Abstract
- Background: Persistent disabilities are key manifestations of Chikungunya virus (CHIKV) infection, especially incapacitating polyarthralgia and fatigue. So far, little is known about their impact on health status. The present study aimed at describing the burden of CHIKV prolonged or late-onset symptoms on the self-perceived health of La Réunion islanders.<br />Methods: At 18 months after an outbreak of Chikungunya virus, we implemented the TELECHIK survey; a retrospective cohort study conducted on a random sample of the representative SEROCHIK population-based survey. A total of 1,094 subjects sampled for CHIKV-specific IgG antibodies in the setting of La Réunion island in the Indian Ocean, between August 2006 and October 2006, were interviewed about current symptoms divided into musculoskeletal/rheumatic, fatigue, cerebral, sensorineural, digestive and dermatological categories.<br />Results: At the time of interview, 43% of seropositive (CHIK+) subjects reported musculoskeletal pain (vs 17% of seronegative (CHIK-) subjects, P < 0.001), 54% fatigue (vs 46%, P = 0.04), 75% cerebral disorders (vs 57%, P < 0.001), 49% sensorineural impairments (vs 37%, P = 0.001), 18% digestive complaints (vs 15%, P = 0.21), and 36% skin involvement (vs 34%, P = 0.20) on average 2 years after infection (range: 15-34 months). After controlling for confounders such as age, gender, body mass index or major comorbidities in different Poisson regression models, 33% of joint pains were attributable to CHIKV, 10% of cerebral disorders and 7.5% of sensorineural impairments, while Chikungunya did not enhance fatigue states, digestive and skin disorders.<br />Conclusions: On average, 2 years after infection 43% to 75% of infected people reported prolonged or late-onset symptoms highly attributable to CHIKV. These manifestations carry a significant burden in the community in the fields of rheumatology, neurology and sensorineural health.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Alphavirus Infections complications
Alphavirus Infections epidemiology
Chikungunya Fever
Child
Child, Preschool
Cohort Studies
Fatigue complications
Fatigue epidemiology
Humans
Infant
Infant, Newborn
Middle Aged
Prevalence
Reunion epidemiology
Rheumatic Diseases complications
Rheumatic Diseases epidemiology
Telephone
Time Factors
Young Adult
Cost of Illness
Disease Outbreaks statistics & numerical data
Health Surveys statistics & numerical data
Residence Characteristics
Subjects
Details
- Language :
- English
- ISSN :
- 1741-7015
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- BMC medicine
- Publication Type :
- Academic Journal
- Accession number :
- 21235760
- Full Text :
- https://doi.org/10.1186/1741-7015-9-5