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A simple head-mountable LED device for chronic stimulation of optogenetic molecules in freely moving mice.
- Source :
-
Neuroscience research [Neurosci Res] 2011 May; Vol. 70 (1), pp. 124-7. Date of Electronic Publication: 2011 Jan 14. - Publication Year :
- 2011
-
Abstract
- We describe a low-cost, small, remotely triggerable LED device for wireless control of transcranial optical stimulation of cortical neurons, for use in freely moving mice. The device is easily mountable on the head of a mouse with a high-polymer block. Using the Thy1-ChR2-YFP transgenic mice, we demonstrate that the device is capable of remotely triggering muscle twitches upon activation of the primary motor cortex in freely moving conditions.<br /> (Copyright © 2011 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.)
- Subjects :
- Animals
Evoked Potentials, Motor physiology
Evoked Potentials, Motor radiation effects
Male
Mice
Mice, Transgenic
Motor Cortex cytology
Motor Cortex physiology
Motor Cortex radiation effects
Pyramidal Cells physiology
Pyramidal Cells radiation effects
Electronics, Medical instrumentation
Electronics, Medical methods
Photic Stimulation instrumentation
Photic Stimulation methods
Voltage-Sensitive Dye Imaging instrumentation
Voltage-Sensitive Dye Imaging methods
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8111
- Volume :
- 70
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroscience research
- Publication Type :
- Academic Journal
- Accession number :
- 21238511
- Full Text :
- https://doi.org/10.1016/j.neures.2011.01.007