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Multiple genetic loci modulate lung adenocarcinoma clinical staging.
- Source :
-
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2011 Apr 15; Vol. 17 (8), pp. 2410-6. Date of Electronic Publication: 2011 Jan 17. - Publication Year :
- 2011
-
Abstract
- Purpose: The main prognostic factor of lung cancer patient outcome is clinical stage, a parameter of tumor aggressiveness. Our study was conducted to test whether germ line variations modulate individual differences in clinical stage.<br />Experimental Design: We conducted a case-only genome-wide association study (GWAS) using a 620,901 single-nucleotide polymorphism (SNP) array in a first series of 600 lung adenocarcinoma (ADCA) patients and in a replication series of 317 lung ADCA patients.<br />Results: GWAS identified 54 putatively associated SNPs, 3 of which were confirmed in the replication series. Joint analysis of the two series pointed to 22 statistically associated (P < 0.01) genetic variants that together explained about 20% of the phenotypic variation in clinical staging (P < 2 × 10(-16)) and showed a statistically significant difference in overall survival (P = 8.0 × 10(-8)). The strongest statistical association was observed at rs10278557 (P = 1.1 × 10(-5)), located in the mesenchyme homeobox 2 (MEOX2) gene.<br />Conclusion: These data point to the role of germ line variations involving multiple loci in modulating clinical stage and, therefore, prognosis in lung ADCA patients.<br /> (©2011 AACR.)
- Subjects :
- Adenocarcinoma pathology
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor genetics
Female
Genetic Loci genetics
Humans
Kaplan-Meier Estimate
Linkage Disequilibrium
Lung Neoplasms pathology
Male
Middle Aged
Neoplasm Staging statistics & numerical data
Polymorphism, Single Nucleotide
Proportional Hazards Models
Young Adult
Adenocarcinoma genetics
Genome-Wide Association Study methods
Lung Neoplasms genetics
Neoplasm Staging methods
Subjects
Details
- Language :
- English
- ISSN :
- 1557-3265
- Volume :
- 17
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Clinical cancer research : an official journal of the American Association for Cancer Research
- Publication Type :
- Academic Journal
- Accession number :
- 21242121
- Full Text :
- https://doi.org/10.1158/1078-0432.CCR-10-2394