Back to Search
Start Over
c-Maf suppresses human T-cell leukemia virus type 1 Tax by competing for CREB-binding protein.
- Source :
-
Cancer science [Cancer Sci] 2011 Apr; Vol. 102 (4), pp. 890-4. Date of Electronic Publication: 2011 Feb 15. - Publication Year :
- 2011
-
Abstract
- Latent infection of human T-cell leukemia virus type 1 (HTLV-1) is considered to be preferentially associated with CCR4(+) CD4(+) T cells. Here we report that c-Maf, one of the critical transcription factors for Th2 differentiation, suppresses the transcriptional activity of HTLV-1 Tax by competing for CREB-binding protein. Notably, c-maf expression is selectively induced in a fraction of CCR4(+) CD4(+) T cells upon activation. Furthermore, c-Maf significantly decreases Tax-induced HTLV-1 envelope gp46 gene expression from an infectious HTLV-1 molecular clone and tax expression in a cell-free HTLV-1 infection system. Collectively, c-Maf may play a role in latent infection of HTLV-1 in CCR4(+) CD4(+) T cells by negatively regulating Tax activity.<br /> (© 2011 Japanese Cancer Association.)
- Subjects :
- Blotting, Western
CD4-Positive T-Lymphocytes metabolism
CD4-Positive T-Lymphocytes virology
CREB-Binding Protein genetics
Cell Transformation, Viral
Gene Products, env genetics
Gene Products, env metabolism
Gene Products, tax antagonists & inhibitors
Gene Products, tax genetics
HTLV-I Infections genetics
HTLV-I Infections virology
Human T-lymphotropic virus 1 genetics
Humans
Jurkat Cells
Leukemia-Lymphoma, Adult T-Cell genetics
Leukemia-Lymphoma, Adult T-Cell metabolism
Leukemia-Lymphoma, Adult T-Cell virology
Luciferases metabolism
Promoter Regions, Genetic
Proto-Oncogene Proteins c-maf antagonists & inhibitors
Proto-Oncogene Proteins c-maf genetics
RNA, Messenger genetics
RNA, Small Interfering genetics
Receptors, CCR4 genetics
Receptors, CCR4 metabolism
Retroviridae Proteins, Oncogenic genetics
Retroviridae Proteins, Oncogenic metabolism
Reverse Transcriptase Polymerase Chain Reaction
Th2 Cells
Transcriptional Activation
Virion
CREB-Binding Protein metabolism
Gene Products, tax metabolism
HTLV-I Infections metabolism
Human T-lymphotropic virus 1 metabolism
Proto-Oncogene Proteins c-maf metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1349-7006
- Volume :
- 102
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cancer science
- Publication Type :
- Academic Journal
- Accession number :
- 21244576
- Full Text :
- https://doi.org/10.1111/j.1349-7006.2011.01873.x