Back to Search
Start Over
Alpha-internexin expression predicts outcome in anaplastic oligodendroglial tumors and may positively impact the efficacy of chemotherapy: European organization for research and treatment of cancer trial 26951.
- Source :
-
Cancer [Cancer] 2011 Jul 01; Vol. 117 (13), pp. 3014-26. Date of Electronic Publication: 2011 Jan 18. - Publication Year :
- 2011
-
Abstract
- Background: Although it has been demonstrated that the neuronal intermediate filament alpha-internexin (INA) is closely related to 1p19q codeletion in gliomas, its prognostic and predictive value has not yet been confirmed in a prospective trial. The authors of this report assessed the prognostic significance of INA expression and its correlation with relevant clinical and molecular characteristics in the prospective, randomized European Organization for Research and Treatment of Cancer (EORTC) 26951 trial of adjuvant procarbazine, lomustine, and vincristine (PCV) in patients with anaplastic oligodendroglial tumors (AOTs).<br />Methods: INA immunohistochemistry expression in tumors from 92 patients who were included in the EORTC 26951 trial was analyzed independently by 2 observers and was correlated with relevant clinical characteristics, including progression-free survival (PFS) and overall survival (OS), and with molecular features, including 1p/19q codeletion, isocitrate dehydrogenase 1 and 2 gene (IDH1/IDH2) mutation, and O-6 methylguanine-DNA methyltransferase (MGMT) promoter methylation status.<br />Results: INA expression was observed in 33 tumors and was strongly correlated with 1p/19q codeletion, IDH1 mutations, and MGMT promoter methylation. It was associated with significantly better PFS and OS independent of the treatment received. By using Cox proportional hazard modeling for OS with stepwise selection, INA expression, patient age, and performance status were identified as independent prognostic factors. The results indicated that INA expression may have an impact on the efficacy of combined radiotherapy plus PCV.<br />Conclusions: In a homogeneously treated group of patients with grade III AOTs, INA expression had strong favorable prognostic significance for OS and may have predictive value for sensitivity to chemotherapy.<br /> (Copyright © 2011 American Cancer Society.)
- Subjects :
- Age Factors
Astrocytoma drug therapy
Astrocytoma metabolism
Astrocytoma radiotherapy
Brain Neoplasms metabolism
Brain Neoplasms radiotherapy
Combined Modality Therapy
DNA Modification Methylases genetics
DNA Repair Enzymes genetics
Disease-Free Survival
Female
Humans
Intermediate Filament Proteins genetics
Isocitrate Dehydrogenase genetics
Lomustine administration & dosage
Lomustine therapeutic use
Male
Oligodendroglioma radiotherapy
Procarbazine administration & dosage
Procarbazine therapeutic use
Prognosis
Proportional Hazards Models
Sequence Deletion
Treatment Outcome
Tumor Suppressor Proteins genetics
Vincristine administration & dosage
Vincristine therapeutic use
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Brain Neoplasms drug therapy
Intermediate Filament Proteins biosynthesis
Oligodendroglioma drug therapy
Oligodendroglioma metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0142
- Volume :
- 117
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 21246521
- Full Text :
- https://doi.org/10.1002/cncr.25827