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Myelin damage of hippocampus and cerebral cortex in rat pentylenetetrazol model.
- Source :
-
Brain research [Brain Res] 2011 Mar 24; Vol. 1381, pp. 208-16. Date of Electronic Publication: 2011 Jan 20. - Publication Year :
- 2011
-
Abstract
- Epilepsy is a chronic neurological disorder characterized by spontaneous recurrent seizures, which also occur in demyelinating diseases of the central nervous system (CNS) with a higher prevalence. Meanwhile, demyelination occurrings have been occasionally observed in CNS of epilepsy patients, indicating an association between demyelination and epileptic seizures by an unknown mechanism. However, no confirmative experimental evidence has yet been given. Thus, by using a rat pentylenetetrazol model, electroencephalogram (EEG), Western blotting, enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry, the present study provided direct evidence that myelin sheath damage in rat hippocampus and cerebral cortex started in the early stage of epileptic seizures induction and lasted with no further increase in severity in the development of epileptic seizures. It was illustrated that myelin sheath damage was not the result of oligodendrocyte destruction, but the autoantibodies against myelin basic protein (MBP) produced in peripheral circulation accompanied by increased permeability of blood-brain barrier (BBB) formed in the development of epileptic seizures. This study firstly provided experimental evidence for myelin sheath damage in PTZ-induced rat's epileptic seizures and further demonstrated that its possible cause was autoimmunoreaction.<br /> (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Autoantibodies metabolism
Blood-Brain Barrier drug effects
Blood-Brain Barrier metabolism
Blood-Brain Barrier pathology
Blotting, Western
Cerebral Cortex drug effects
Cerebral Cortex metabolism
Electroencephalography
Enzyme-Linked Immunosorbent Assay
Epilepsy chemically induced
Epilepsy metabolism
Hippocampus drug effects
Hippocampus metabolism
Immunohistochemistry
Male
Myelin Basic Protein metabolism
Myelin Sheath drug effects
Myelin Sheath metabolism
Nerve Fibers, Myelinated drug effects
Nerve Fibers, Myelinated metabolism
Oligodendroglia drug effects
Oligodendroglia metabolism
Oligodendroglia pathology
Pentylenetetrazole
Rats
Rats, Sprague-Dawley
Cerebral Cortex pathology
Epilepsy pathology
Hippocampus pathology
Myelin Sheath pathology
Nerve Fibers, Myelinated pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-6240
- Volume :
- 1381
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 21256118
- Full Text :
- https://doi.org/10.1016/j.brainres.2011.01.011