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Acetylthiocholine (ATC)--cleaving cholinesterase (ChE) activity as a potential biomarker of pesticide exposure in the Manila clam, Ruditapes philippinarum, of Korea.
- Source :
-
Marine environmental research [Mar Environ Res] 2011 Apr; Vol. 71 (3), pp. 162-8. Date of Electronic Publication: 2011 Jan 05. - Publication Year :
- 2011
-
Abstract
- The acetylthiocholine (ATC) - cleaving cholinesterase (ChE) activity in Manila clam, which is widely distributed throughout the coastal environment of Korea, was assayed as a potentially useful biomarker of organophosphorous pesticides (OPs). A clear dose-response relationship was determined between inhibited ChE in adductor muscle of clams and four OPs (methidathion, chlorpyrifos, diazinon, IBP) which are heavily used OPs in Korea. The measured EC(50)-24 h values of methidathion, chlorpyrifos, diazinon, and IBP for Ruditapes philippinarum were 7.16 μg l(-1), 0.34 mg l(-1), 3.01 mg l(-1), and 3.41 mg l(-1), respectively. In field studies, ChE activity in Manila clams collected from 23 stations in the mid-western coastal region demonstrated spatial variation with statistical differences. These results suggest that ChE activity in R. philippinarum is a potential biomarker for assessing organophosphorous pesticide contamination in coastal environments.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Bivalvia metabolism
Chlorpyrifos toxicity
Diazinon toxicity
Dose-Response Relationship, Drug
Organothiophosphorus Compounds toxicity
Republic of Korea
Water Pollutants, Chemical toxicity
Acetylthiocholine metabolism
Bivalvia drug effects
Cholinesterase Inhibitors toxicity
Cholinesterases metabolism
Pesticides toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0291
- Volume :
- 71
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Marine environmental research
- Publication Type :
- Academic Journal
- Accession number :
- 21262527
- Full Text :
- https://doi.org/10.1016/j.marenvres.2010.12.007