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Human CD4+ FOXP3+ regulatory T cells produce CXCL8 and recruit neutrophils.
- Source :
-
European journal of immunology [Eur J Immunol] 2011 Feb; Vol. 41 (2), pp. 306-12. Date of Electronic Publication: 2011 Jan 11. - Publication Year :
- 2011
-
Abstract
- One of the defining features of the majority of FOXP3(+) Tregs is their inability to produce typical T-cell-derived cytokines. Little is known, however, about their capacity to produce chemokines. As Tregs are constitutively present in, and rapidly traffic to, non-lymphoid tissues, we hypothesized that they may produce chemokines to direct the composition of cells that infiltrate inflamed tissues. Surprisingly, we found that Tregs produce high amounts of CXCL8 (IL-8), a potent neutrophil chemoattractant. Tregs also produced other CC and CXC family chemokines, including CCL2-5, CCL7, and CXCL10. Whereas ectopic expression of FOXP3 suppressed cytokine production, it significantly induced CXCL8. Moreover, supernatants from Tregs attracted neutrophils via a CXCL8-dependent mechanism. These data provide the first evidence that although classical Tregs are defined by their lack of proinflammatory cytokine production, they secrete significant quantities of chemokines and thus may have an unappreciated role in directing the recruitment of immune cells.<br /> (Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Antibodies, Monoclonal immunology
Antibodies, Monoclonal pharmacology
Chemokines, CC metabolism
Chemokines, CXC metabolism
Chemotaxis drug effects
Culture Media, Conditioned pharmacology
Forkhead Transcription Factors genetics
Gene Expression Regulation immunology
Humans
Interleukin-2 Receptor alpha Subunit metabolism
Interleukin-8 genetics
Interleukin-8 immunology
Neutrophils cytology
Neutrophils drug effects
Transduction, Genetic
Chemotaxis immunology
Forkhead Transcription Factors metabolism
Interleukin-8 metabolism
Neutrophils immunology
T-Lymphocytes, Regulatory immunology
T-Lymphocytes, Regulatory metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4141
- Volume :
- 41
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 21268001
- Full Text :
- https://doi.org/10.1002/eji.201040459