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Symptoms of attention-deficit/hyperactivity disorder in long-term survivors of childhood leukemia.
- Source :
-
Pediatric blood & cancer [Pediatr Blood Cancer] 2011 Dec 15; Vol. 57 (7), pp. 1191-6. Date of Electronic Publication: 2011 Jan 28. - Publication Year :
- 2011
-
Abstract
- Background: Survivors of childhood acute lymphoblastic leukemia (ALL) sometimes have clinical features that suggest attention-deficit/hyperactivity disorder (ADHD), though few studies have examined specific symptoms in survivors.<br />Procedure: Long-term survivors of childhood ALL (n = 161) received a neurological examination, while parents completed rating scales to establish formal criteria for ADHD. Symptom profiles were generated and compared across demographic and treatment characteristics, as well as medical tests associated with brain pathology.<br />Results: Prevalence rates of ADHD were similar in survivors (10.5%) compared to those reported in the general population (7-10%). However, 25.5% of survivors reported symptoms that impair functioning in multiple settings, with attention problems being most common. These symptoms were associated with cranial radiation therapy (CRT) (mean inattentive symptoms [SD] = 3.6 [3.19] for group treated with CRT vs. 1.6 [2.40] for non-CRT group, P = 0.0006), and survivors who demonstrated impaired anti-saccades during the neurologic exam (mean inattentive symptoms [SD] = 3.4 [3.29] for those with impaired anti-saccades vs. 1.4 [2.41] for those with normal anti-saccades; P = 0.0004).<br />Conclusions: The presence of a neurologically-based phenotype of attention problems in survivors of leukemia that is not fully captured by the syndrome of ADHD suggests that treatments specific to childhood ALL should be explored.<br /> (Copyright © 2011 Wiley Periodicals, Inc.)
- Subjects :
- Adolescent
Adult
Child
Cranial Irradiation adverse effects
Female
Humans
Leukemia therapy
Male
Neurologic Examination
Prevalence
Young Adult
Attention Deficit Disorder with Hyperactivity epidemiology
Attention Deficit Disorder with Hyperactivity etiology
Leukemia complications
Survivors psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1545-5017
- Volume :
- 57
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Pediatric blood & cancer
- Publication Type :
- Academic Journal
- Accession number :
- 21280202
- Full Text :
- https://doi.org/10.1002/pbc.22994