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Carotid intima media thickness is associated with plasma lipoprotein-associated phospholipase A2 mass in nondiabetic subjects but not in patients with type 2 diabetes.
- Source :
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European journal of clinical investigation [Eur J Clin Invest] 2011 Aug; Vol. 41 (8), pp. 820-7. Date of Electronic Publication: 2011 Jan 31. - Publication Year :
- 2011
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Abstract
- Background: A recent meta-analysis showed that both plasma lipoprotein-associated phospholipase A(2) (Lp-PLA(2) ) mass and activity independently predict cardiovascular events. Notably, Lp-PLA(2) activity but not mass was found to be a determinant of cardiovascular outcome in type 2 diabetes mellitus. We questioned whether relationships of carotid intima media thickness (IMT), a measure of subclinical atherosclerosis, with Lp-PLA(2) mass differ between diabetic and nondiabetic subjects.<br />Materials and Methods: Relationships of IMT with plasma Lp-PLA(2) mass (turbidimetric immunoassay) were compared in 74 patients with type 2 diabetes and in 64 nondiabetic subjects.<br />Results: IMT was increased (P=0·016), but plasma Lp-PLA(2) mass was decreased in patients with diabetes compared to nondiabetic subjects (277±66 vs. 327±62μgL(-1) , P<0·001). In nondiabetic subjects, IMT was correlated positively with Lp-PLA(2) (r=0·325, P<0·009); multiple linear regression analysis confirmed an independent association of IMT with Lp-PLA(2) (ß=0·192, P=0·048). In contrast, IMT was unrelated to Lp-PLA(2) in patients with diabetes (r=0·021, P=0·86), and the relationship of IMT with Lp-PLA(2) was different in diabetic and control subjects (P<0·001). The relationship of Lp-PLA(2) with the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio also differed between diabetic and nondiabetic subjects (P<0·001).<br />Conclusions: Plasma Lp-PLA(2) may relate to early stages of atherosclerosis development. In diabetes mellitus, in contrast, the association of IMT with plasma Lp-PLA(2) mass is abolished, which could be partly ascribed to redistribution of Lp-PLA(2) mass from apolipoprotein B-containing lipoproteins towards HDL. These findings raise questions about the usefulness of plasma Lp-PLA(2) mass measurement as a marker of subclinical atherosclerosis in type 2 diabetes mellitus.<br /> (© 2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation.)
- Subjects :
- Aged
Atherosclerosis diagnostic imaging
Case-Control Studies
Diabetes Mellitus, Type 2 diagnostic imaging
Female
Humans
Male
Middle Aged
Regression Analysis
White People
1-Alkyl-2-acetylglycerophosphocholine Esterase blood
Atherosclerosis physiopathology
Carotid Intima-Media Thickness
Diabetes Mellitus, Type 2 physiopathology
Tunica Intima diagnostic imaging
Tunica Media diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2362
- Volume :
- 41
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- European journal of clinical investigation
- Publication Type :
- Academic Journal
- Accession number :
- 21281278
- Full Text :
- https://doi.org/10.1111/j.1365-2362.2011.02471.x