Back to Search
Start Over
[Mutant prevention concentrations of garenoxacin against Streptococcus pneumoniae isolates from otorhinolaryngological infections].
- Source :
-
The Japanese journal of antibiotics [Jpn J Antibiot] 2010 Aug; Vol. 63 (4), pp. 312-8. - Publication Year :
- 2010
-
Abstract
- The minimum inhibitory concentrations (MICs) and the mutant prevention concentrations (MPCs) of garenoxacin (GRNX), were compared to those of levofloxacin (LVFX), and moxifloxacin (MFLX) against 78 Streptococcus pneumoniae isolates from otorhinolaryngological infections in Japan during the period January 2007 to June 2007. The MIC and MPC for 90% of the isolates (MIC90 and MPC90) of GRNX were 0.06 and 0.12 microg/mL, respectively, and were the lower values than LVFX and MFLX MIC90s and MPC90s. The ratios of MPC/MIC of GRNX were the lower values than those of LVFX and MFLX.
- Subjects :
- Aza Compounds pharmacology
Dose-Response Relationship, Drug
Drug Resistance, Bacterial genetics
Humans
Levofloxacin
Moxifloxacin
Ofloxacin pharmacology
Quinolines pharmacology
Streptococcus pneumoniae isolation & purification
Anti-Bacterial Agents pharmacology
Fluoroquinolones pharmacology
Mutation
Otorhinolaryngologic Diseases microbiology
Otorhinolaryngologic Diseases prevention & control
Pneumococcal Infections microbiology
Pneumococcal Infections prevention & control
Streptococcus pneumoniae drug effects
Streptococcus pneumoniae genetics
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0368-2781
- Volume :
- 63
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Japanese journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 21298864