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Targeted biocompatible nanoparticles for the delivery of (-)-epigallocatechin 3-gallate to prostate cancer cells.
- Source :
-
Journal of medicinal chemistry [J Med Chem] 2011 Mar 10; Vol. 54 (5), pp. 1321-32. Date of Electronic Publication: 2011 Feb 09. - Publication Year :
- 2011
-
Abstract
- Molecular targeted cancer therapy mediated by nanoparticles (NPs) is a promising strategy to overcome the lack of specificity of conventional chemotherapeutic agents. In this context, the prostate-specific membrane antigen (PSMA) has demonstrated a powerful potential for the management of prostate cancer (PCa). Cancer chemoprevention by phytochemicals is emerging as a suitable approach for the treatment of early carcinogenic processes. Since (-)-epigallocatechin 3-gallate (EGCG) has shown potent chemopreventive efficacy for PCa, we designed and developed novel targeted NPs in order to selectively deliver EGCG to cancer cells. Herein, to explore the recent concept of "nanochemoprevention", we present a study on EGCG-loaded NPs consisting of biocompatible polymers, functionalized with small molecules targeting PSMA, that exhibited a selective in vitro efficacy against PSMA-expressing PCa cells. This approach could be beneficial for high risk patients and would fulfill a significant therapeutic need, thus opening new perspectives for novel and effective treatment for PCa.
- Subjects :
- Anticarcinogenic Agents chemistry
Anticarcinogenic Agents pharmacology
Catalytic Domain
Catechin administration & dosage
Catechin chemistry
Catechin pharmacology
Cell Line, Tumor
Cell Proliferation drug effects
Dipeptides chemistry
Humans
Kinetics
Male
Molecular Targeted Therapy
Polyesters chemistry
Prostate-Specific Antigen metabolism
Prostatic Neoplasms metabolism
Anticarcinogenic Agents administration & dosage
Catechin analogs & derivatives
Dipeptides chemical synthesis
Drug Carriers
Nanoparticles
Polyesters chemical synthesis
Prostatic Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1520-4804
- Volume :
- 54
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 21306166
- Full Text :
- https://doi.org/10.1021/jm1013715