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Neuronal genes for subcutaneous fat thickness in human and pig are identified by local genomic sequencing and combined SNP association study.
- Source :
-
PloS one [PLoS One] 2011 Feb 02; Vol. 6 (2), pp. e16356. Date of Electronic Publication: 2011 Feb 02. - Publication Year :
- 2011
-
Abstract
- Obesity represents a major global public health problem that increases the risk for cardiovascular or metabolic disease. The pigs represent an exceptional biomedical model related to energy metabolism and obesity in humans. To pinpoint causal genetic factors for a common form of obesity, we conducted local genomic de novo sequencing, 18.2 Mb, of a porcine QTL region affecting fatness traits, and carried out SNP association studies for backfat thickness and intramuscular fat content in pigs. In order to relate the association studies in pigs to human obesity, we performed a targeted genome wide association study for subcutaneous fat thickness in a cohort population of 8,842 Korean individuals. These combined association studies in human and pig revealed a significant SNP located in a gene family with sequence similarity 73, member A (FAM73A) associated with subscapular skin-fold thickness in humans (rs4121165, GC-corrected p-value = 0.0000175) and with backfat thickness in pigs (ASGA0029495, p-value = 0.000031). Our combined association studies also suggest that eight neuronal genes are responsible for subcutaneous fat thickness: NEGR1, SLC44A5, PDE4B, LPHN2, ELTD1, ST6GALNAC3, ST6GALNAC5, and TTLL7. These results provide strong support for a major involvement of the CNS in the genetic predisposition to a common form of obesity.
- Subjects :
- Adiposity genetics
Adult
Aged
Animals
Cohort Studies
Female
Genome
Humans
Male
Middle Aged
Nerve Tissue Proteins genetics
Nerve Tissue Proteins metabolism
Organ Size
Polymorphism, Single Nucleotide physiology
Quantitative Trait Loci genetics
Skinfold Thickness
Sus scrofa anatomy & histology
Sus scrofa metabolism
Genes physiology
Genome-Wide Association Study methods
Neurons metabolism
Sequence Analysis, DNA methods
Subcutaneous Fat anatomy & histology
Sus scrofa genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 6
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 21311593
- Full Text :
- https://doi.org/10.1371/journal.pone.0016356