Back to Search
Start Over
Giant cell hepatitis and autoimmune hemolytic anemia after chickenpox.
- Source :
-
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology [Turk J Gastroenterol] 2010 Dec; Vol. 21 (4), pp. 448-51. - Publication Year :
- 2010
-
Abstract
- Autoimmune hemolytic anemia with giant cell hepatitis is a distinct entity in children. It is usually fatal with progressive liver disease. Immunosuppressive treatment with conventional drugs offers some response; however, it is usually only temporary. Alternative therapeutic options with monoclonals have been reported with promising remission of the disease. We report a case with autoimmune hemolytic anemia+giant cell hepatitis after varicella infection. She was resistant to standard immunosuppressive combinations, and rescue therapy with rituximab was used. Remission was not achieved with the drug and the child died with septic complication.
- Subjects :
- Anemia, Hemolytic, Autoimmune drug therapy
Antibodies, Monoclonal, Murine-Derived therapeutic use
Chickenpox immunology
Fatal Outcome
Female
Giant Cells immunology
Giant Cells pathology
Hepatitis drug therapy
Humans
Immunologic Factors therapeutic use
Infant
Rituximab
Anemia, Hemolytic, Autoimmune pathology
Anemia, Hemolytic, Autoimmune virology
Chickenpox complications
Hepatitis pathology
Hepatitis virology
Subjects
Details
- Language :
- English
- ISSN :
- 2148-5607
- Volume :
- 21
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 21332002
- Full Text :
- https://doi.org/10.4318/tjg.2010.0135