Human lymph node development: An inflammatory interaction.

Authors :: Cupedo T
Source :: Immunology letters [Immunol Lett] 2011 Jul; Vol. 138 (1), pp. 4-6. Date of Electronic Publication: 2011 Feb 17.
Publication Year :: 2011
Abstract: In the developing human fetus, lymph nodes and Peyer's patches are formed during the first and second trimester of pregnancy. The cells responsible for this process, lymphoid tissue inducer (LTi) cells, share a number of characteristics with Natural Killer (NK) cells and produce cytokines related to inflammation. Here I will discuss recent advances in our understanding of human lymph node development, in particular the characterization of LTi cells and the relationship of these innate lymphocytes to conventional NK cells.<br /> (Copyright © 2011 Elsevier B.V. All rights reserved.)