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The overexpression of AP-4 as a prognostic indicator for gastric carcinoma.
- Source :
-
Medical oncology (Northwood, London, England) [Med Oncol] 2012 Jun; Vol. 29 (2), pp. 871-7. Date of Electronic Publication: 2011 Feb 20. - Publication Year :
- 2012
-
Abstract
- As a transcription factor belonging to the basic helix-loop-helix leucine-zipper subgroup, AP-4 can control target gene expression by altering cell signal transduction, and regulate growth, development, and cell apoptosis. Under pathological circumstances, it is involved in tumorigenesis. Herein, immunohistochemistry and real-time PCR were used to detect the transcription factor AP-4 expression in gastric cancer, and these data were examined for correlation with histology, pTNM stage, and prognosis. The AP-4 expression rate was 83.67% in a total of 98 gastric cancer tissues, which was significantly higher than 40.91% in non-neoplastic tissues; AP-4 mRNA relative expression shows a significant difference between gastric cancer and normal tissues, and AP-4 expression has a significantly positive correlation with the depth of tumor invasion (P < 0.0001), degree of tumor differentiation (P = 0.0058), lymph node metastasis (P = 0.0255), and pTNM stage (P = 0.001). Survival analysis showed that AP-4-positive patients' median survival time (12.60 months) was significantly shorter than that (41.40 months) of AP-4-negative patients. AP-4 expression in gastric cancer is associated with clinicopathological parameters of gastric cancer, such as differentiation, lymph node metastasis, depth of invasion (P = 0.0010), and pTNM stage. What's more, AP-4 overexpression indicated a worse prognosis for patients. So AP-4 may be a molecular marker to predict the progression and prognosis of the tumor.
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers, Tumor genetics
Case-Control Studies
DNA-Binding Proteins genetics
Female
Follow-Up Studies
Gastric Mucosa metabolism
Humans
Immunoenzyme Techniques
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Prognosis
RNA, Messenger genetics
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Stomach pathology
Stomach Neoplasms mortality
Stomach Neoplasms pathology
Survival Rate
Transcription Factors genetics
Young Adult
Biomarkers, Tumor metabolism
DNA-Binding Proteins metabolism
Stomach Neoplasms metabolism
Transcription Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1559-131X
- Volume :
- 29
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Medical oncology (Northwood, London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 21336989
- Full Text :
- https://doi.org/10.1007/s12032-011-9845-8